Hematinic deficiencies and anemia statuses in recurrent aphthous stomatitis patients with or without atrophic glossitis

Yang-Che Wu; Yu-Hsueh Wu; Yi-Ping Wang; Julia Yu-Fong Chang; Hsin-Ming Chen; Andy Sun

doi:10.1016/j.jfma.2016.10.007

Hematinic deficiencies and anemia statuses in recurrent aphthous stomatitis patients with or without atrophic glossitis

J Formos Med Assoc. 2016 Dec;115(12):1061-1068. doi: 10.1016/j.jfma.2016.10.007. Epub 2016 Nov 7.

Authors

Yang-Che Wu¹, Yu-Hsueh Wu¹, Yi-Ping Wang², Julia Yu-Fong Chang², Hsin-Ming Chen², Andy Sun³

Affiliations

¹ Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
² Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.
³ Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: andysun7702@yahoo.com.tw.

PMID: 27839675
DOI: 10.1016/j.jfma.2016.10.007

Abstract

Background/purpose: Some of recurrent aphthous stomatitis (RAS) patients had concomitant atrophic glossitis (AG). This study assessed whether RAS patients with AG (AG+/RAS patients) or without AG (AG-/RAS patients) had anemia and hematinic deficiencies and to evaluate whether RAS combined with AG or RAS itself was a significant factor causing anemia and hematinic deficiencies in AG+/RAS or AG-/RAS patients, respectively.

Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of three groups of 160 AG+/RAS patients, 195 AG-/RAS patients, and 355 healthy control subjects.

Results: Both AG+/RAS and AG-/RAS patients had significantly lower mean Hb, iron, and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, vitamin B12, and folic acid deficiencies than healthy control subjects. Moreover, AG+/RAS patients had significantly lower mean Hb and serum iron level (for women only) and significantly greater frequencies of Hb and iron deficiencies than AG-/RAS patients. Of 69 anemia AG+/RAS patients, 30 (43.5%) had normocytic anemia and 23 (33.3%) had iron deficiency anemia. Of 38 anemia AG-/RAS patients, 26 (68.4%) had normocytic anemia and 5 (13.2%) had iron deficiency anemia.

Conclusion: We conclude that some of AG+/RAS or AG-/RAS patients do have anemia and hematinic deficiencies and AG+/RAS patients do have severer anemia statuses and iron deficiency than AG-/RAS patients. RAS combined with AG or RAS itself does play a significant role in causing anemia and hematinic deficiencies in AG+/RAS or AG-/RAS patients, respectively.

Keywords: Anemia; Atrophic glossitis; Hematinic deficiency; Iron; Recurrent aphthous stomatitis; Vitamin B12.

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Anemia / epidemiology
Anemia / etiology*
Anemia, Iron-Deficiency / epidemiology
Anemia, Iron-Deficiency / etiology
Atrophy / blood
Atrophy / complications
Case-Control Studies
Erythrocyte Indices
Female
Folic Acid / blood
Folic Acid Deficiency / epidemiology
Folic Acid Deficiency / etiology
Glossitis / blood*
Glossitis / complications
Hematinics / blood*
Hemoglobins / analysis
Humans
Iron / blood
Male
Middle Aged
Recurrence
Risk Factors
Stomatitis, Aphthous / blood*
Stomatitis, Aphthous / complications
Tongue / pathology*
Vitamin B 12 / blood
Vitamin B 12 Deficiency / epidemiology
Vitamin B 12 Deficiency / etiology
Young Adult

Substances

Hematinics
Hemoglobins
Folic Acid
Iron
Vitamin B 12