Abstract
The liver-X-receptors have shown anti-fibrosis ability in several animal models. Our purpose was to investigate the effect of LXRs in bleomycin induced lung fibrosis in mice. Bleomycin was intratracheally delivered to mice. Some mice were administered a LXR agonist, T0901317. Then mice were evaluated for the development of lung inflammation and fibrosis. T0901317 was able to attenuate the inflammation and fibrosis induced by bleomycin. T0901317 treatment evidently abolished the high level of TGF-β1 and inhibited NF-κB DNA-binding activity in lung. So LXRs may attenuate the progressing of lung fibrosis, providing a potential treatment of IPF.
Keywords:
Bleomycin; Liver X receptors; Pulmonary fibrosis.
Copyright © 2016 Elsevier B.V. All rights reserved.
MeSH terms
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ATP Binding Cassette Transporter 1 / genetics
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Animals
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Anti-Inflammatory Agents / pharmacology
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Anti-Inflammatory Agents / therapeutic use*
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Bleomycin
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Bronchoalveolar Lavage Fluid / chemistry
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Cytokines / metabolism
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Female
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Fibronectins / metabolism
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Hydrocarbons, Fluorinated / pharmacology
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Hydrocarbons, Fluorinated / therapeutic use*
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Ligands
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Liver X Receptors / metabolism
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Lung / drug effects
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Lung / metabolism
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Lung / pathology
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Mice, Inbred C57BL
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NF-kappa B / metabolism
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Pulmonary Fibrosis / chemically induced
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Pulmonary Fibrosis / drug therapy*
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Pulmonary Fibrosis / metabolism
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Pulmonary Fibrosis / pathology
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RNA, Messenger / metabolism
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Serpin E2 / metabolism
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Sulfonamides / pharmacology
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Sulfonamides / therapeutic use*
Substances
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ABCA1 protein, mouse
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ATP Binding Cassette Transporter 1
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Anti-Inflammatory Agents
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Cytokines
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Fibronectins
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Hydrocarbons, Fluorinated
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Ligands
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Liver X Receptors
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NF-kappa B
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RNA, Messenger
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Serpin E2
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Serpine2 protein, mouse
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Sulfonamides
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T0901317
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Bleomycin