Early enteric neuron dysfunction in mouse and human Huntington disease

Parkinsonism Relat Disord. 2017 Jan:34:73-74. doi: 10.1016/j.parkreldis.2016.10.017. Epub 2016 Nov 1.

Authors

Serena Sciacca¹, Mariagrazia Favellato², Michele Madonna¹, Daniela Metro³, Massimo Marano⁴, Ferdinando Squitieri⁵

Affiliations

¹ IRCCS Neuromed, Pozzilli, Italy.
² Milan, Italy.
³ Istituto di Fisiologia Umana, Università di Messina, Messina, Italy.
⁴ Fondazione LIRH onlus, Rome, Italy; IRCCS Casa Sollievo della Sofferenza Hospital - Mendel Institute of Human Genetics, Rome, Italy; Università Campus Bio-Medico, Rome, Italy.
⁵ IRCCS Casa Sollievo della Sofferenza Hospital - Mendel Institute of Human Genetics, Rome, Italy. Electronic address: f.squitieri@css-mendel.it.

PMID: 27836713
DOI: 10.1016/j.parkreldis.2016.10.017

No abstract available

Keywords: Enteric neurons; Huntingtin; Huntington disease; Intestinal dysfunction; Neuropeptides.

Publication types

Case Reports
Letter

MeSH terms

Animals
Disease Models, Animal
Female
Humans
Huntingtin Protein / genetics
Huntington Disease / complications*
Huntington Disease / genetics
Huntington Disease / pathology
Intestinal Pseudo-Obstruction / etiology*
Intestinal Pseudo-Obstruction / pathology
Mice
Mice, Transgenic
Middle Aged
Neurons / metabolism
Neurons / pathology*
Neuropeptides / metabolism

Substances

Htt protein, mouse
Huntingtin Protein
Neuropeptides