Bio-inspired engineering proteinosomes with a cell-wall-like protective shell by self-assembly of a metal-chelated complex

Dongyue Su; Xiaoman Liu; Lei Wang; Chao Ma; Hui Xie; Hao Zhang; Xianghe Meng; Yudong Huang; Xin Huang

doi:10.1039/c6cc07655f

Bio-inspired engineering proteinosomes with a cell-wall-like protective shell by self-assembly of a metal-chelated complex

Chem Commun (Camb). 2016 Dec 11;52(95):13803-13806. doi: 10.1039/c6cc07655f. Epub 2016 Nov 10.

Authors

Dongyue Su¹, Xiaoman Liu, Lei Wang, Chao Ma, Hui Xie, Hao Zhang, Xianghe Meng, Yudong Huang, Xin Huang

Affiliation

¹ MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China. liuxiaoman@hit.edu.cn xinhuang@hit.edu.cn.

PMID: 27831577
DOI: 10.1039/c6cc07655f

Abstract

A cell-wall-like shell is constructed around proteinosomes by coordination complexes of tannic acid and Fe³⁺, which endows the engineered proteinosomes with an enhanced Young's modulus of the membrane, protease resistant ability, EDTA-mediated release of loaded DNA, and electrostatic gated encapsulated enzyme activity, as well as antioxidant capacity.

MeSH terms

Antioxidants / chemistry
Cell Wall / chemistry
Cell Wall / metabolism*
Coordination Complexes / chemistry
Coordination Complexes / metabolism*
DNA / metabolism
Edetic Acid
Peptide Hydrolases / chemistry*
Peptide Hydrolases / metabolism*
Protein Engineering*
Static Electricity
Tannins / chemistry

Substances

Antioxidants
Coordination Complexes
Tannins
DNA
Edetic Acid
Peptide Hydrolases