Abstract
Leukotriene B4 receptor 1 (BLT1), a high-affinity G protein-coupled receptor (GPCR) for leukotriene B4 (LTB4), plays important roles in inflammatory and immune reactions. Although the LTB4-BLT1 axis is known to promote inflammation, the binding proteins that modulate LTB4-BLT1 signaling have not been identified. Recently, we discovered that receptor for advanced glycation end products (RAGE) interacts with BLT1 and modulates LTB4-BLT1 signaling. We propose RAGE as a new class of GPCR modulator and a new target of future GPCR studies.
Keywords:
G protein-coupled receptor; leukotriene B4 receptor 1; receptor for advanced glycation end products.
MeSH terms
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Gene Expression Regulation
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Humans
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Inflammation
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Leukocytes, Mononuclear / immunology*
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Leukocytes, Mononuclear / pathology
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Leukotriene B4 / immunology
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Leukotriene B4 / metabolism*
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MAP Kinase Signaling System / genetics
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MAP Kinase Signaling System / immunology
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Macrophages / immunology*
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Macrophages / pathology
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Mitogen-Activated Protein Kinase 1 / genetics
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Mitogen-Activated Protein Kinase 1 / immunology
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Mitogen-Activated Protein Kinase 3 / genetics
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Mitogen-Activated Protein Kinase 3 / immunology
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NF-kappa B / genetics
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NF-kappa B / immunology
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Phosphorylation
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Receptor for Advanced Glycation End Products / genetics*
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Receptor for Advanced Glycation End Products / immunology
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Receptors, Leukotriene B4 / genetics*
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Receptors, Leukotriene B4 / immunology
Substances
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AGER protein, human
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LTB4R protein, human
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NF-kappa B
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Receptor for Advanced Glycation End Products
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Receptors, Leukotriene B4
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Leukotriene B4
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MAPK1 protein, human
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Mitogen-Activated Protein Kinase 1
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Mitogen-Activated Protein Kinase 3