Furofuran lignan glucosides from the leaves of Vitex negundo var. cannabifolia

Nat Prod Res. 2017 Apr;31(8):918-924. doi: 10.1080/14786419.2016.1255887. Epub 2016 Nov 10.

Abstract

Two new furofuran lignan glucosides, cannabilignin (1) and isocannabilignin (2), together with four known compounds (3-6), were isolated from the leaves of Vitex negundo var. cannabifolia. The structures of the isolates were elucidated by analysis of spectroscopic data. Compound 3 exhibited weak inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC50 value of 69.1 ± 5.8 μM.

Keywords: Verbenaceae; Vitex negundo var. cannabifolia; lignan glucoside.

MeSH terms

  • Animals
  • Cell Line
  • Drug Evaluation, Preclinical / methods
  • Glucosides / chemistry
  • Glucosides / isolation & purification
  • Glucosides / pharmacology*
  • Inhibitory Concentration 50
  • Lignans / chemistry*
  • Lignans / pharmacology
  • Lipopolysaccharides / pharmacology
  • Mice
  • Microglia / drug effects
  • Microglia / metabolism
  • Molecular Structure
  • Nitric Oxide / biosynthesis
  • Plant Leaves / chemistry
  • Vitex / chemistry*

Substances

  • Glucosides
  • Lignans
  • Lipopolysaccharides
  • cannabilignin
  • Nitric Oxide