Abstract
The liver has an important function in the human body and plays a crucial role in its metabolism. Orthotopic liver transplantation (OLT) is the gold standard treatment for patients presenting liver failure or end stage liver diseases, and is also applied for liver based intractable metabolic disorders. Due to organ shortage, invasive surgery and persistent mortality/morbidity, other treatments have to be explored. Amongst these, hepatocyte transplantation is an attractive alternative and has shown promising results in the treatment of miscellaneous metabolic disorders.
Keywords:
Children; Hepatic metabolic disorder; Hepatocyte isolation; Liver cell transplantation; Liver failure.
MeSH terms
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Cell Differentiation
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Cell Separation / instrumentation
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Cell Separation / methods*
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Cell Survival
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Cell Transplantation / instrumentation
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Cell Transplantation / methods*
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Child
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Cryopreservation / instrumentation
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Cryopreservation / methods*
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Donor Selection / methods
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Donor Selection / standards
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End Stage Liver Disease / surgery
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Graft Rejection / prevention & control
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Hepatocytes / physiology
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Hepatocytes / transplantation*
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Humans
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Immunosuppression Therapy / methods
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Liver / cytology
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Liver / metabolism
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Liver / surgery*
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Liver Transplantation / adverse effects
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Liver Transplantation / methods
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Mesenchymal Stem Cell Transplantation / methods
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Mesenchymal Stem Cells / physiology
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Metabolic Diseases / surgery*
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Primary Cell Culture / methods
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Tissue and Organ Harvesting / methods