An unusual case of basal cell carcinoma of the vulva with lung metastases

G A Watson; D Kelly; L Prior; E Stanley; O MacEneaney; T Walsh; C M Kelly

doi:10.1016/j.gore.2016.10.005

An unusual case of basal cell carcinoma of the vulva with lung metastases

Gynecol Oncol Rep. 2016 Oct 25:18:32-35. doi: 10.1016/j.gore.2016.10.005. eCollection 2016 Nov.

Authors

G A Watson¹, D Kelly¹, L Prior¹, E Stanley², O MacEneaney³, T Walsh⁴, C M Kelly¹

Affiliations

¹ Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.
² Department of Radiology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.
³ Department of Pathology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.
⁴ Department of Gynaecology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.

Abstract

Basal cell carcinoma (BCC) is the most common non-melanomatous skin cancer, typically arising in sun-exposed areas such as the head and neck. Defective signaling through the Hedgehog (HH) signaling pathway forms the molecular basis for BCC. Surgery remains the mainstay of treatment. Basal cell carcinoma of the genital tract is rare as is metastatic BCC. We report a case of metastatic BCC in a young woman with previously resected vulval BCC presenting six years later with inguinal nodal recurrence and multiple lung metastases.

Keywords: Basal cell carcinoma; Hedgehog pathway; Lung metastasis; SMO inhibitors; Vismodegib; Vulva.

Publication types

Case Reports