Common functions of the chloroplast and mitochondrial co-chaperones cpDnaJL (CDF1) and mtDnaJ (PAM16) in protein import and ROS scavenging in Arabidopsis thaliana

John Gray; Sachin Rustgi; Diter von Wettstein; Christiane Reinbothe; Steffen Reinbothe

doi:10.1080/19420889.2015.1119343

Common functions of the chloroplast and mitochondrial co-chaperones cpDnaJL (CDF1) and mtDnaJ (PAM16) in protein import and ROS scavenging in Arabidopsis thaliana

Commun Integr Biol. 2015 Dec 9;9(5):e1119343. doi: 10.1080/19420889.2015.1119343. eCollection 2016.

Authors

John Gray¹, Sachin Rustgi², Diter von Wettstein², Christiane Reinbothe³, Steffen Reinbothe³

Affiliations

¹ Department of Biological Sciences, University of Toledo , Toledo, OH, USA.
² Department of Crop and Soil Sciences, School of Molecular Biosciences, Center for Reproductive Biology, Washington State University , Pullman, WA, USA.
³ Biologie Environnementale et systémique (BEeSy), Université Joseph Fourier , Grenoble, France.

Abstract

As semi-autonomous cell organelles that contain only limited coding information in their own DNA, chloroplasts and mitochondria must import the vast majority of their protein constituents from the cytosol. Respective protein import machineries have been identified that mediate the uptake of chloroplast and mitochondrial proteins and interact with molecular chaperones of the HEAT-SHOCK PROTEIN (HSP) 70 family operating as import motors. Recent work identified unexpected new functions of 2 DnaJ co-chaperones in mitochondrial and chloroplast protein translocation and suggest a common mechanism of reactive oxygen species (ROS) scavenging that shall be discussed here.

Keywords: CDF1 (cell growth defect factor 1); DnaJ-like co-chaperones (holdases); PAM (presequence translocase-associated protein import motor); ROS (reactive oxygen species); mitochondria and chloroplasts; organelle biogenesis.

Publication types

Review