Metabolic Signaling Drives IFN-γ

Peter J Siska; Jeffrey C Rathmell

doi:10.1016/j.cmet.2016.10.018

Metabolic Signaling Drives IFN-γ

Cell Metab. 2016 Nov 8;24(5):651-652. doi: 10.1016/j.cmet.2016.10.018.

Authors

Peter J Siska¹, Jeffrey C Rathmell²

Affiliations

¹ Department of Pathology, Microbiology and Immunology, Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN 37232-2363, USA.
² Department of Pathology, Microbiology and Immunology, Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN 37232-2363, USA. Electronic address: jeff.rathmell@vanderbilt.edu.

Abstract

IFN-γ is a critical inflammatory cytokine that is closely regulated to cellular metabolic status and requires high rates of glycolysis. It has now been shown that a key mechanism to link these pathways is through maintenance of acetyl-CoA and epigenetic regulation of the IFNG locus.

Publication types

Comment

MeSH terms

Cytokines
Epigenesis, Genetic*
Humans
Interferon-gamma / genetics*
Promoter Regions, Genetic
Signal Transduction

Substances

Cytokines
Interferon-gamma

Grants and funding

R01 DK105550/DK/NIDDK NIH HHS/United States