Aim: To investigate the expression of TRIP13 in multiple tumors and to evaluate the relationship between TRIP13 and survival of cancer patients.
Materials & methods: Sample expression profiles were downloaded from the gene expression omnibus database. Correlation between TRIP13 expression and clinicopathological features was analyzed by χ2 test. Patient survival was evaluated by Kaplan-Meier analysis.
Results: TRIP13 expression was upregulated in 12 cancer types; it significantly correlated with multiple clinicopathological features of breast, liver and lung cancer. High TRIP13 expression indicated poor prognosis of patients with breast, liver, gastric and lung cancer.
Conclusion: TRIP13 is highly expressed in multiple tumors and may be used as a potential prognostic marker and therapeutic target.
Keywords: cancer biomarkers; poor prognosis; thyroid hormone receptor-interacting protein 13.