Influence of Contrast Agent Dilution on Ballon Deflation Time and Visibility During Tracheal Balloon Dilation: A 3D Printed Phantom Study

Cardiovasc Intervent Radiol. 2017 Feb;40(2):285-290. doi: 10.1007/s00270-016-1497-9. Epub 2016 Nov 8.

Abstract

Purpose: To determine the effect of contrast medium dilution during tracheal balloon dilation on balloon deflation time and visibility using a 3-dimensional (3D) printed airway phantom.

Materials and methods: A comparison study to investigate balloon deflation times and image quality was performed using two contrast agents with different viscosities, i.e., iohexol and ioxithalamate, and six contrast dilutions with a 3D printed airway phantom.

Results: Compared to 1:0 concentration, 3:1, 2:1, 1:1, 1:2, and 1:3, contrast/saline ratios resulted in a 46% (56.2 s), 59.8% (73.1 s), 74.9% (91.6 s), 81.7% (99.8 s), and 83.5% (102 s) reduction for iohexol, respectively, and a 51.8% (54.7 s), 63.8% (67.6 s), 74.7% (79.2 s), 80.5% (85.3 s), and 82.4% (87.4 s) reduction for ioxithalamate, respectively, in the mean balloon deflation time, although at the expense of decreased balloon opacity (3.5, 6.9, 11.1, 12.4, and 13.9%, for iohexol, respectively, and 3.2, 6, 9.6, 10.8, and 12.4%, for ioxithalamate, respectively).

Conclusions: Use of a lower viscosity contrast agent and higher contrast dilution is considered to be able to reduce balloon deflation times and then simultaneously decrease visualization of balloons. The rapid balloon deflation time is likely to improve the safe performance of interventional procedures.

Keywords: Balloon catheter; Deflation time; Obstruction; Tracheal Stricture.

MeSH terms

  • Contrast Media*
  • Dilatation / instrumentation*
  • Dilatation / methods
  • Dilatation / statistics & numerical data*
  • Dose-Response Relationship, Drug
  • Humans
  • Iohexol
  • Iothalamic Acid / analogs & derivatives
  • Phantoms, Imaging*
  • Printing, Three-Dimensional*
  • Time Factors
  • Trachea
  • Tracheal Stenosis / therapy*

Substances

  • Contrast Media
  • Iothalamic Acid
  • Iohexol
  • ioxitalamic acid