Endothelial dysfunction has been implicated in the pathophysiology of multiple cardiovascular diseases and involves components of both innate and acquired immune mechanisms. Identifying signature patterns and targets associated with endothelial dysfunction can help in the development of novel nanotherapeutic platforms for treatment of vascular diseases. This review discusses nucleic acid-based regulation of endothelial function and the different nucleic acid-based nanotherapeutic approaches designed to target endothelial dysfunction in cardiovascular disorders.
Keywords: CVD; DNA damage; cardiovascular diseases; endothelium; inflammation; miRNA; nanoparticle delivery; nucleic acids; oligonucleotide-based therapeutics; oxidative stress.