Metabolic Control of Cellular Differentiation

Vinay Bulusu; Alexander Aulehla

doi:10.1016/j.devcel.2016.10.019

Metabolic Control of Cellular Differentiation

Dev Cell. 2016 Nov 7;39(3):286-287. doi: 10.1016/j.devcel.2016.10.019.

Authors

Vinay Bulusu¹, Alexander Aulehla²

Affiliations

¹ Cancer Metabolism Research Unit, Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK.
² Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstraße 1, Heidelberg 69117, Germany. Electronic address: aulehla@embl.de.

PMID: 27825439
DOI: 10.1016/j.devcel.2016.10.019

Abstract

The role of metabolic rewiring during cellular differentiation is under intense investigation. Reporting recently in Science, Peng et al. (2016) found that activation of glycolysis supports T helper cell differentiation by controlling acetyl-coA and histone acetylation levels, identifying a link between metabolic state and epigenetic control of gene activity.

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Comment

MeSH terms

Acetyl Coenzyme A / genetics*
Acetylation
Cell Differentiation
Histones / genetics*
Protein Processing, Post-Translational

Substances

Histones
Acetyl Coenzyme A