There is a growing research activity focusing on the brain heart cross-talk. A great variety of brain disorders affect the heart and recent developments in neurosciences have revealed the particular role of specific neuroanatomic sites on heart rhythm and rate, myocardial function and vascular tone. Cardiac radionuclide imaging plays a pivotal role in this setting, since not only helps elucidating underlying pathobiological mechanisms but in addition, it promises exciting possibilities for early identification of patients at risk of developing cardiovascular manifestations of certain neurological diseases.