The aim of our retrospective study was to evaluate the diagnostic and therapeutic characteristics of 100 patients who were admitted in our psychiatric department from an index date. Previous investigation showed high prevalence of comorbidity in patients with psychiatric disorders. The most common psychiatric comorbidities included dementia (20%), alcohol dependence (14%) and unipolar depression (8%). The presence of somatic diseases was also high (73%), including cardiovascular (55%), endocrine (30%), neurological (17%), and gastroenterological (16 %) comorbid disorders. The most frequent diagnostic and/or differential diagnostic procedures performed were: x-ray (28%), ultrasound (28%), CT-scan (24%), EEG (24 %). Our results: 1. in accordance with previous studies we also found a high number of somatic comorbid conditions among the patients hospitalised in the psychiatric ward 2. it is very important to recognize and treat the somatic conditions of patients hospitalized in psychiatric departments. The complex diagnostic procedures and the introduction of adequate therapies may help to reduce mortality and improve quality of life of the patients.