NKp46 Is an NK Cell Fungicidal Pattern Recognition Receptor

Shu Shun Li; Christopher H Mody

doi:10.1016/j.tim.2016.10.002

NKp46 Is an NK Cell Fungicidal Pattern Recognition Receptor

Trends Microbiol. 2016 Dec;24(12):929-931. doi: 10.1016/j.tim.2016.10.002. Epub 2016 Nov 3.

Authors

Shu Shun Li¹, Christopher H Mody²

Affiliations

¹ Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Canada; The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Canada. Electronic address: shusli@ucalgary.ca.
² Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Canada; The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Canada; Department of Medicine, University of Calgary, Calgary, Canada. Electronic address: cmody@ucalgary.ca.

PMID: 27816327
DOI: 10.1016/j.tim.2016.10.002

Abstract

Natural killer (NK) cells are an important contributor to innate host defense because of their role in direct microbial recognition and killing. Vitenshtein et al. make an important contribution by demonstrating that NK cells kill Candida glabrata using the NK activating receptor, NKp46, which recognizes the Epa adhesins.

Keywords: fungi; innate immunity; natural cytotoxic receptors; natural killer cells.

Publication types

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MeSH terms

Killer Cells, Natural*
Natural Cytotoxicity Triggering Receptor 1*
Receptors, Pattern Recognition

Substances

Natural Cytotoxicity Triggering Receptor 1
Receptors, Pattern Recognition