LSD1 Makes Fat Colorful

Leon G Straub; Christian Wolfrum

doi:10.1016/j.tem.2016.10.006

LSD1 Makes Fat Colorful

Trends Endocrinol Metab. 2017 Jan;28(1):1-2. doi: 10.1016/j.tem.2016.10.006. Epub 2016 Nov 1.

Authors

Leon G Straub¹, Christian Wolfrum²

Affiliations

¹ Institute of Food, Nutrition, and Health, Eidgenössische Technische Hochschule (ETH) Zürich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland.
² Institute of Food, Nutrition, and Health, Eidgenössische Technische Hochschule (ETH) Zürich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland. Electronic address: christian-wolfrum@ethz.ch.

PMID: 27814942
DOI: 10.1016/j.tem.2016.10.006

Abstract

The histone lysine-specific demethylase 1 (LSD1) is a new and important player in the regulation of brown fat identity and function. In a recent Cell Reports article, Duteil et al. show that LSD1 exerts its effects via regulation of specific histone marks as well as through association with co-repressor complexes.

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MeSH terms

Animals
Histone Demethylases / genetics
Histone Demethylases / metabolism*
Histones / metabolism
Humans
Lipid Metabolism / genetics
Lipid Metabolism / physiology
Transcription, Genetic / genetics

Substances

Histones
Histone Demethylases
KDM1A protein, human