Inflammatory biomarkers of coronary heart disease

Front Biosci (Landmark Ed). 2017 Jan 1;22(3):504-515. doi: 10.2741/4498.

Abstract

Coronary heart disease (CHD), characterized by inflammation and accumulation of plaques mainly comprised of lipids, calcium and inflammatory cells in the walls of coronary arteries. CHD is exacerbated by specific cardiovascular risk factors, such as obesity, diabetes mellitus, and hypertension. The current review focuses on the critical role of traditional inflammatory biomarkers, including interleukin-6, C-reactive protein (CRP), complement, CD40 and myeloperoxidase (MPO), in the pathogenesis of CHD.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / blood
  • C-Reactive Protein / metabolism
  • CD40 Antigens / blood
  • CD40 Ligand / blood
  • Complement System Proteins / metabolism
  • Coronary Artery Disease / blood
  • Coronary Artery Disease / etiology
  • Coronary Disease / blood*
  • Coronary Disease / etiology
  • Humans
  • Inflammation Mediators / blood*
  • Models, Cardiovascular
  • Peroxidase / blood
  • Receptors, Interleukin-6 / blood
  • Serum Amyloid A Protein / metabolism

Substances

  • Biomarkers
  • CD40 Antigens
  • IL6R protein, human
  • Inflammation Mediators
  • Receptors, Interleukin-6
  • Serum Amyloid A Protein
  • CD40 Ligand
  • Complement System Proteins
  • C-Reactive Protein
  • Peroxidase