Computational Biomechanics of Human Red Blood Cells in Hematological Disorders

Xuejin Li; He Li; Hung-Yu Chang; George Lykotrafitis; George Em Karniadakis

doi:10.1115/1.4035120

Computational Biomechanics of Human Red Blood Cells in Hematological Disorders

J Biomech Eng. 2017 Feb 1;139(2):0210081-02100813. doi: 10.1115/1.4035120.

Authors

Xuejin Li¹, He Li², Hung-Yu Chang², George Lykotrafitis³, George Em Karniadakis⁴

Affiliations

¹ Division of Applied Mathematics, Brown University, Providence, RI 02912 e-mail: Xuejin_Li@brown.edu.
² Division of Applied Mathematics, Brown University, Providence, RI 02912.
³ Department of Mechanical Engineering, University of Connecticut, Storrs, CT 06269;Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269.
⁴ Fellow ASME Division of Applied Mathematics, Brown University, Providence, RI 02912 e-mail: George_Karniadakis@brown.edu.

Abstract

We review recent advances in multiscale modeling of the biomechanical characteristics of red blood cells (RBCs) in hematological diseases, and their relevance to the structure and dynamics of defective RBCs. We highlight examples of successful simulations of blood disorders including malaria and other hereditary disorders, such as sickle-cell anemia, spherocytosis, and elliptocytosis.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Blood Flow Velocity*
Cell Size
Compressive Strength
Computer Simulation
Elastic Modulus
Erythrocytes / physiology*
Hematologic Diseases / blood*
Hematologic Diseases / physiopathology*
Humans
Models, Cardiovascular*
Rheology / methods
Shear Strength
Stress, Mechanical
Tensile Strength

Abstract

Publication types

MeSH terms

Grants and funding