DNA Walkers as Transport Vehicles of Nanoparticles Along a Carbon Nanotube Track

Jing Pan; Tae-Gon Cha; Haorong Chen; Feiran Li; Jong Hyun Choi

doi:10.1007/978-1-4939-6454-3_19

DNA Walkers as Transport Vehicles of Nanoparticles Along a Carbon Nanotube Track

Methods Mol Biol. 2017:1500:269-280. doi: 10.1007/978-1-4939-6454-3_19.

Authors

Jing Pan¹, Tae-Gon Cha¹, Haorong Chen¹, Feiran Li¹, Jong Hyun Choi²

Affiliations

¹ School of Mechanical Engineering, Purdue University, Mechanical Engineering Building Room 2143, 585 Purdue Mall, West Lafayette, IN, 47907, USA.
² School of Mechanical Engineering, Purdue University, Mechanical Engineering Building Room 2143, 585 Purdue Mall, West Lafayette, IN, 47907, USA. jchoi@purdue.edu.

PMID: 27813015
DOI: 10.1007/978-1-4939-6454-3_19

Abstract

DNA-based molecular motors are synthetic analogs of naturally occurring protein motors. Typical DNA walkers are constructed from synthetic short DNA strands and are powered by various free energy changes during hybridization reactions. Due to the constraints set by their small physical dimension and slow kinetics, most DNA walkers are characterized by ensemble measurements that result in averaged kinetics data. Here we present a synthetic DNA walker system that exploits the extraordinary physicochemical properties of nanomaterials and the functionalities of DNA molecules, which enables real-time control and monitoring of single-DNA walkers over an extended period.

Keywords: Carbon nanotube; DNA enzyme; DNA walker; Photo-regulation; Quantum dot.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

DNA / chemistry*
Molecular Motor Proteins / chemistry*
Nanoparticles / chemistry*
Nanostructures / chemistry
Nanotechnology / methods
Nanotubes, Carbon / chemistry*
Nucleic Acid Hybridization / methods

Substances

Molecular Motor Proteins
Nanotubes, Carbon
DNA