Abstract
AMP-activated protein kinase (AMPK) is one of the central regulators of cellular and organismal metabolism in eukaryotes. Once activated by decreased energy levels, it induces ATP production by promoting catabolic pathways while conserving ATP by inhibiting anabolic pathways. AMPK plays a crucial role in various aspects of cellular function such as regulating growth, reprogramming metabolism, autophagy, and cell polarity. In this chapter, we focus on how recent breakthroughs made using the model organism Caenorhabditis elegans have contributed to our understanding of AMPK function and how it can be utilized in the future to elucidate hitherto unknown aspects of AMPK signaling.
Keywords:
AAK-2; AMPK; Caenorhabditis elegans; Dauer; Diapause; Germline stem cell quiescence; Lifespan; Longevity.
MeSH terms
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AMP-Activated Protein Kinases / genetics*
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AMP-Activated Protein Kinases / metabolism
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Animals
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Autophagy / genetics
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Caenorhabditis elegans / genetics*
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Caenorhabditis elegans / metabolism
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Caenorhabditis elegans Proteins / genetics
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Caenorhabditis elegans Proteins / metabolism
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Caloric Restriction
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Forkhead Transcription Factors / genetics
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Forkhead Transcription Factors / metabolism
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Gene Expression Regulation*
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Gonads / metabolism
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Insulin / genetics
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Insulin / metabolism
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Insulin-Like Growth Factor I / genetics
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Insulin-Like Growth Factor I / metabolism
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Lipid Metabolism / genetics
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Longevity / genetics*
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Mitochondria / genetics
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Mitochondria / metabolism
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Protein Subunits / genetics
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Protein Subunits / metabolism
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Signal Transduction / genetics*
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TOR Serine-Threonine Kinases / genetics
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TOR Serine-Threonine Kinases / metabolism
Substances
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Caenorhabditis elegans Proteins
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Forkhead Transcription Factors
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Insulin
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Protein Subunits
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daf-16 protein, C elegans
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Insulin-Like Growth Factor I
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TOR Serine-Threonine Kinases
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AMP-Activated Protein Kinases