Macrolactam analogues of macrolide natural products

Helmut M Hügel; Andrew T Smith; Mark A Rizzacasa

doi:10.1039/c6ob02149b

Macrolactam analogues of macrolide natural products

Org Biomol Chem. 2016 Dec 7;14(48):11301-11316. doi: 10.1039/c6ob02149b.

Authors

Helmut M Hügel¹, Andrew T Smith², Mark A Rizzacasa³

Affiliations

¹ School of Science & Biomedical and Health Innovations Enabling Capability Platform, RMIT University, GPO Box 2476, Melbourne, VIC 3001, Australia. helmut.hugel@rmit.edu.au.
² Griffith Sciences, Gold Coast campus, Griffith University, QLD 4222, Australia.
³ School of Chemistry, the Bio21 Institute, The University of Melbourne, VIC 3010, Australia. masr@unimelb.edu.au.

PMID: 27812587
DOI: 10.1039/c6ob02149b

Abstract

The chemical modification of macrolide natural products into aza- or lactam analogues is a strategy employed to improve their metabolic stability and biological activity. The methods for the synthesis of several lactam analogues of macrolide natural products are highlighted and aspects of their biological properties presented.

Publication types

Review

MeSH terms

Anti-Bacterial Agents / chemical synthesis
Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology
Bacteria / drug effects
Biological Products / chemistry*
Biological Products / pharmacology
Lactams, Macrocyclic / chemical synthesis
Lactams, Macrocyclic / chemistry*
Lactams, Macrocyclic / pharmacology
Macrolides / chemistry*
Macrolides / pharmacology
Models, Molecular
Molecular Conformation

Substances

Anti-Bacterial Agents
Biological Products
Lactams, Macrocyclic
Macrolides