Resveratrol post-treatment protects against neonatal brain injury after hypoxia-ischemia

Oncotarget. 2016 Nov 29;7(48):79247-79261. doi: 10.18632/oncotarget.13018.

Abstract

Neonatal hypoxic-ischemic brain injury is a devastating disease with limited treatment options. Preventive treatment with resveratrol has indicated to be well tolerated and has lower toxicity in both experimental models and human patients. However, whether resveratrol administration post-hypoxic-ischemic protects against neonatal hypoxic-ischemic injury is not known. Here we reported that post-treatment with resveratrol significantly reduced brain damage at 7-day after the injury. We found that resveratrol reduced the expression levels of key inflammatory factors at the mRNA and protein levels, and at least partially via inhibiting microglia activation. Moreover, resveratrol exerted an anti-apoptotic effect, as assessed by TUNEL staining, and altered the expression of the apoptosis-related genes Bax, Bcl-2 and caspase3. Our data indicate that post-treatment with resveratrol protects against neonatal hypoxic-ischemic brain injury and suggest a promising therapeutic strategy to this disease.

Keywords: apoptosis; brain damage; hypoxia-ischemia; inflammation; resveratrol.

MeSH terms

  • Animals
  • Animals, Newborn
  • Brain Injuries / etiology
  • Brain Injuries / immunology
  • Brain Injuries / pathology
  • Brain Injuries / prevention & control*
  • Caspase 3 / metabolism
  • Cytokines / genetics
  • Cytokines / metabolism
  • Disease Models, Animal
  • Gene Expression Regulation / drug effects
  • Hypoxia-Ischemia, Brain / complications*
  • Hypoxia-Ischemia, Brain / immunology
  • Hypoxia-Ischemia, Brain / pathology
  • Male
  • Microglia / drug effects
  • Microglia / pathology
  • Neuroprotective Agents / administration & dosage*
  • Neuroprotective Agents / pharmacology
  • Proto-Oncogene Proteins c-bcl-2 / genetics
  • Proto-Oncogene Proteins c-bcl-2 / metabolism
  • Rats
  • Resveratrol
  • Stilbenes / administration & dosage*
  • Stilbenes / pharmacology
  • bcl-2-Associated X Protein / genetics
  • bcl-2-Associated X Protein / metabolism

Substances

  • Bax protein, rat
  • Bcl2 protein, rat
  • Cytokines
  • Neuroprotective Agents
  • Proto-Oncogene Proteins c-bcl-2
  • Stilbenes
  • bcl-2-Associated X Protein
  • Casp3 protein, rat
  • Caspase 3
  • Resveratrol