Many studies have highlighted significant interactions between soil C reservoir dynamics and global climate and environmental change. However, in order to estimate the future soil organic carbon sequestration potential and related ecosystem services well, more spatially detailed predictions are needed. The present study made detailed predictions of future spatial evolution (at 250 m resolution) of topsoil SOC driven by climate change and land use change for France up to the year 2100 by taking interactions between climate, land use and soil type into account. We conclude that climate change will have a much bigger influence on future SOC losses in mid-latitude mineral soils than land use change dynamics. Hence, reducing CO2 emissions will be crucial to prevent further loss of carbon from our soils.