Abstract
Chemical investigation of Aspergillus japonicus CAM231, isolated from the leaf of Garcina preussii collected in Cameroon, yielded two new compounds; one pyrone derivative, hydroxy neovasinin (1) and one phenol derivative, asperolan (2), together with two known compounds neovasifurarone B (3) and variecolin (4). The structures of the two new compounds were established using intensive NMR spectroscopy and HRMS spectra in comparison with data found in literature. The structure of compound 1 was confirmed by single-crystal X-ray crystallographic analysis in combination with NOESY experiment. The new compounds were screened for their cytotoxic and antibacterial properties; however, the tested compounds displayed no significant activities.
Keywords:
Aspergillus japonicus CAM231; endophytic fungus; secondary metabolites.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Aspergillus / chemistry
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Aspergillus / metabolism*
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Breast Neoplasms / drug therapy
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Breast Neoplasms / pathology
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Cameroon
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Cell Line, Tumor
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Crystallography, X-Ray
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Drug Evaluation, Preclinical
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Endophytes / metabolism
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Furans / isolation & purification*
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Garcinia / microbiology*
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Humans
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Molecular Structure
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Phenols / isolation & purification*
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Pyrones / chemistry
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Pyrones / isolation & purification*
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Pyrones / metabolism
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Secondary Metabolism
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Terpenes / isolation & purification
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Terpenes / metabolism
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Furans
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Phenols
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Pyrones
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Terpenes
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asperolan
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hydroxy neovasinin
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neovasifurarone B
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variecolin