trans- and cis-(Cl,Cl)-[RuII(FT)Cl2(NO)](PF6): promising candidates for NO release in the NIR region

Joelle Akl; Isabelle Sasaki; Pascal G Lacroix; Vincent Hugues; Patricia Vicendo; Mathilde Bocé; Sonia Mallet-Ladeira; Mireille Blanchard-Desce; Isabelle Malfant

doi:10.1039/c6pp00181e

trans- and cis-(Cl,Cl)-[Ru^II(FT)Cl₂(NO)](PF₆): promising candidates for NO release in the NIR region

Photochem Photobiol Sci. 2016 Nov 30;15(12):1484-1491. doi: 10.1039/c6pp00181e.

Authors

Joelle Akl¹, Isabelle Sasaki¹, Pascal G Lacroix¹, Vincent Hugues², Patricia Vicendo³, Mathilde Bocé⁴, Sonia Mallet-Ladeira¹, Mireille Blanchard-Desce², Isabelle Malfant¹

Affiliations

¹ Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, F-31077 Toulouse, France. isabelle.malfant@lcc-toulouse.fr.
² Institute of Molecular Sciences (CNRS UMR 5255), 351 cours de la libération 33405, Talence Cedex, France.
³ Laboratoire des Interactions Moléculaires et de la Réactivité Chimique et Photochimique, Université Paul Sabatier 118 route de Narbonne, F-31062 Toulouse, France.
⁴ Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, F-31077 Toulouse, France. isabelle.malfant@lcc-toulouse.fr and Institut de Pharmacologie et de Biologie Structurale, 205 route de Narbonne, F-31077 Toulouse, France.

PMID: 27805228
DOI: 10.1039/c6pp00181e

Abstract

cis- and trans-(Cl,Cl)-[Ru^II(FT)Cl₂(NO)](PF₆) complexes show efficient NO photodelivery upon two-photon excitation in the NIR region. Moreover, cytotoxicity and phototoxicity studies provide evidence that these complexes are promising candidates as photoactivatable molecular tools for resection of malignancies.

MeSH terms

Antineoplastic Agents / chemistry*
Infrared Rays*
Nitric Oxide / metabolism*
Phototherapy*

Substances

Antineoplastic Agents
Nitric Oxide