[Pharmacological analysis of SGLT2 inhibitor (tofogliflozin) using in vivo glucose clamp and titration protocols in rats and cynomolgus monkeys]

Nihon Yakurigaku Zasshi. 2016;148(5):259-265. doi: 10.1254/fpj.148.259.
[Article in Japanese]
No abstract available

MeSH terms

  • Animals
  • Benzhydryl Compounds / pharmacology*
  • Glucose / metabolism
  • Glucose Clamp Technique
  • Glucosides / pharmacology*
  • Humans
  • Hypoglycemic Agents / pharmacology*
  • Kidney / drug effects
  • Kidney / metabolism
  • Macaca fascicularis
  • Rats

Substances

  • Benzhydryl Compounds
  • Glucosides
  • Hypoglycemic Agents
  • Glucose
  • 6-((4-ethylphenyl)methyl)-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)spiro(isobenzofuran-1(3H),2'-(2H)pyran)-3',4',5'-triol