Effect of Alcoholic Intoxication on the Risk of Inflammatory Bowel Disease: A Nationwide Retrospective Cohort Study

Tai-Yi Hsu; Hong-Mo Shih; Yu-Chiao Wang; Leng-Chieh Lin; Guan-Yi He; Chih-Yu Chen; Chia-Hung Kao; Chao-Hsien Chen; Wei-Kung Chen; Tse-Yen Yang

doi:10.1371/journal.pone.0165411

Effect of Alcoholic Intoxication on the Risk of Inflammatory Bowel Disease: A Nationwide Retrospective Cohort Study

PLoS One. 2016 Nov 1;11(11):e0165411. doi: 10.1371/journal.pone.0165411. eCollection 2016.

Authors

Tai-Yi Hsu^{1

2}, Hong-Mo Shih^{1

2}, Yu-Chiao Wang^{2

3}, Leng-Chieh Lin^{4

5}, Guan-Yi He^{6

7}, Chih-Yu Chen^{1

2}, Chia-Hung Kao^{8

9

10}, Chao-Hsien Chen¹¹, Wei-Kung Chen^{1

2}, Tse-Yen Yang^{11

12}

Affiliations

¹ Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan.
² School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
³ Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
⁴ Department of Emergency Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan.
⁵ Department of Nursing, Chang Gung University of Science and Technology, Chiayi, Taiwan.
⁶ Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
⁷ Department of Dermatology, National Taiwan University Hospital Yunlin Branch, Douliou, Taiwan.
⁸ Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
⁹ Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan.
¹⁰ Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan.
¹¹ Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan.
¹² Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.

Abstract

Purpose: This study investigated whether alcoholic intoxication (AI) increases the risk of inflammatory bowel disease (IBD) by using a population-based database in Taiwan.

Methods: This retrospective matched-cohort study included 57 611 inpatients with new-onset AI (AI cohort) and 230 444 randomly selected controls (non-AI cohort). Each patient was monitored for 10 years to individually identify those who were subsequently diagnosed with Crohn disease (CD) and ulcerative colitis (UC) during the follow-up period. Cox proportional hazard regression analysis was conducted to determine the risk of IBD in patients with AI compared with controls without AI.

Results: The incidence rate of IBD during the 10-year follow-up period was 2.69 per 1 000 person-years and 0.49 per 1 000 person-years in the AI and non-AI cohorts, respectively. After adjustment for age, sex, and comorbidity, the AI cohort exhibited a 3.17-fold increased risk of IBD compared with the non-AI cohort (hazard ratio [HR] = 3.17, 95% confidence interval [CI] = 2.19-4.58). Compared with the non-AI cohort, the HRs of CD and UC were 4.40 and 2.33 for the AI cohort, respectively. After stratification for the severity of AI according to the duration of hospital stay, the adjusted HRs exhibited a significant correlation with the severity; the HRs of IBD were 1.76, 6.83, and 19.9 for patients with mild, moderate, and severe AI, respectively (p for the trend < .0001).

Conclusion: The risk of IBD was higher in patients with AI and increased with the length of hospital stay.

MeSH terms

Adult
Age Factors
Aged
Alcoholic Intoxication / complications*
Female
Follow-Up Studies
Hospitalization
Humans
Incidence
Inflammatory Bowel Diseases / etiology*
Male
Middle Aged
Retrospective Studies
Risk Factors
Sex Factors
Taiwan / epidemiology

Grants and funding

This study is supported in part by Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence (MOHW105-TDU-B-212-133019), China Medical University Hospital, Academia Sinica Taiwan Biobank Stroke Biosignature Project (BM10501010037), NRPB Stroke Clinical Trial Consortium (MOST 104-2325-B-039 -005), Tseng-Lien Lin Foundation, Taichung, Taiwan, Taiwan Brain Disease Foundation, Taipei, Taiwan, and Katsuzo and Kiyo Aoshima Memorial Funds, Japan; and CMU under the Aim for Top University Plan of the Ministry of Education, Taiwan. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.