Meta-Analysis of Effect Sizes Reported at Multiple Time Points Using General Linear Mixed Model

PLoS One. 2016 Oct 31;11(10):e0164898. doi: 10.1371/journal.pone.0164898. eCollection 2016.

Abstract

Meta-analysis of longitudinal studies combines effect sizes measured at pre-determined time points. The most common approach involves performing separate univariate meta-analyses at individual time points. This simplistic approach ignores dependence between longitudinal effect sizes, which might result in less precise parameter estimates. In this paper, we show how to conduct a meta-analysis of longitudinal effect sizes where we contrast different covariance structures for dependence between effect sizes, both within and between studies. We propose new combinations of covariance structures for the dependence between effect size and utilize a practical example involving meta-analysis of 17 trials comparing postoperative treatments for a type of cancer, where survival is measured at 6, 12, 18 and 24 months post randomization. Although the results from this particular data set show the benefit of accounting for within-study serial correlation between effect sizes, simulations are required to confirm these results.

MeSH terms

  • Algorithms
  • Combined Modality Therapy
  • Humans
  • Likelihood Functions
  • Linear Models*
  • Longitudinal Studies
  • Meta-Analysis as Topic*
  • Models, Statistical
  • Neoplasms / mortality
  • Neoplasms / therapy
  • Odds Ratio
  • Postoperative Care
  • Research Design
  • Sample Size

Grants and funding

The author(s) received no specific funding for this work.