Hepatic Telocytes

Adv Exp Med Biol. 2016:913:425-432. doi: 10.1007/978-981-10-1061-3_27.

Abstract

Telocytes (TCs), a novel peculiar interstitial cell found in many tissues and organs, play pivotal roles in maintaining tissue homeostasis and regulating tissue and organ development and immune surveillance. In recent years, the existence of TCs in liver has been confirmed. In this chapter, we evaluate the role of TCs on promoting liver regeneration and the therapeutic effects on liver fibrosis.

Keywords: Liver; Liver fibrosis; Liver regeneration; Telocytes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD34 / genetics
  • Antigens, CD34 / metabolism
  • Biomarkers / metabolism
  • Gene Expression
  • Homeostasis / physiology
  • Humans
  • Immunohistochemistry
  • Liver / metabolism
  • Liver / ultrastructure*
  • Liver Cirrhosis / genetics
  • Liver Cirrhosis / metabolism
  • Liver Cirrhosis / pathology*
  • Liver Regeneration / physiology*
  • Mice
  • Microscopy, Electron, Transmission
  • Proto-Oncogene Proteins c-kit / genetics
  • Proto-Oncogene Proteins c-kit / metabolism
  • Receptor, Platelet-Derived Growth Factor beta / genetics
  • Receptor, Platelet-Derived Growth Factor beta / metabolism
  • Telocytes / metabolism
  • Telocytes / ultrastructure*

Substances

  • Antigens, CD34
  • Biomarkers
  • Proto-Oncogene Proteins c-kit
  • Receptor, Platelet-Derived Growth Factor beta