Discovery of Anticancer Agents of Diverse Natural Origin

A Douglas Kinghorn; Esperanza J Carcache DE Blanco; David M Lucas; H Liva Rakotondraibe; Jimmy Orjala; D Doel Soejarto; Nicholas H Oberlies; Cedric J Pearce; Mansukh C Wani; Brent R Stockwell; Joanna E Burdette; Steven M Swanson; James R Fuchs; Mitchell A Phelps; Lihui Xu; Xiaoli Zhang; Young Yongchun Shen

doi:10.21873/anticanres.11146

Discovery of Anticancer Agents of Diverse Natural Origin

Anticancer Res. 2016 Nov;36(11):5623-5637. doi: 10.21873/anticanres.11146.

Authors

A Douglas Kinghorn^{1

2}, Esperanza J Carcache DE Blanco³, David M Lucas^{2

4}, H Liva Rakotondraibe³, Jimmy Orjala⁵, D Doel Soejarto^{5

6}, Nicholas H Oberlies⁷, Cedric J Pearce⁸, Mansukh C Wani⁹, Brent R Stockwell^{10

11}, Joanna E Burdette⁵, Steven M Swanson¹², James R Fuchs³, Mitchell A Phelps^{3

2}, Lihui Xu², Xiaoli Zhang^{2

4}, Young Yongchun Shen¹³

Affiliations

¹ College of Pharmacy, The Ohio State University, Columbus, OH, U.S.A. kinghorn.4@osu.edu.
² Comprehensive Cancer Center, The Ohio State University, Columbus, OH, U.S.A.
³ College of Pharmacy, The Ohio State University, Columbus, OH, U.S.A.
⁴ College of Medicine, The Ohio State University, Columbus, OH, U.S.A.
⁵ College of Pharmacy, University of Illinois at Chicago, Chicago, IL, U.S.A.
⁶ Field Museum of Natural History, Chicago, IL, U.S.A.
⁷ Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, U.S.A.
⁸ Mycosynthetix, Inc., Hillsborough, NC, U.S.A.
⁹ Research Triangle Institute, Research Triangle Park, NC, U.S.A.
¹⁰ Department of Biological Sciences, Columbia University, New York, NY, U.S.A.
¹¹ Department of Chemistry, Columbia University, New York, NY, U.S.A.
¹² School of Pharmacy, University of Wisconsin-Madison, Madison, WI, U.S.A.
¹³ Eisai Inc., Andover, MA, U.S.A.

Abstract

Recent progress is described in an ongoing collaborative multidisciplinary research project directed towards the purification, structural characterization, chemical modification, and biological evaluation of new potential natural product anticancer agents obtained from a diverse group of organisms, comprising tropical plants, aquatic and terrestrial cyanobacteria, and filamentous fungi. Information is provided on how these organisms are collected and processed. The types of bioassays are indicated in which initial extracts, chromatographic fractions, and purified isolated compounds of these acquisitions are tested. Several promising biologically active lead compounds from each major organism class investigated are described, and these may be seen to be representative of a very wide chemical diversity.

Keywords: Natural products; cyanobacteria; fungi; potential anticancer activity; review; tropical plants.

Publication types

Review

MeSH terms

Antineoplastic Agents / therapeutic use*
Biological Products / therapeutic use*
Drug Discovery*
Humans
Neoplasms / drug therapy*

Substances

Antineoplastic Agents
Biological Products

Abstract

Publication types

MeSH terms

Substances

Grants and funding