Palladium(0)-Catalyzed Intermolecular Arylative Dearomatization of β-Naphthols

Ren-Qi Xu; Ping Yang; Hang-Fei Tu; Shou-Guo Wang; Shu-Li You

doi:10.1002/anie.201608724

Palladium(0)-Catalyzed Intermolecular Arylative Dearomatization of β-Naphthols

Angew Chem Int Ed Engl. 2016 Nov 21;55(48):15137-15141. doi: 10.1002/anie.201608724. Epub 2016 Oct 28.

Authors

Ren-Qi Xu¹, Ping Yang¹, Hang-Fei Tu¹, Shou-Guo Wang¹, Shu-Li You¹

Affiliation

¹ State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai, 200032, China.

PMID: 27791314
DOI: 10.1002/anie.201608724

Abstract

The first Pd⁰ -catalyzed intermolecular arylative dearomatization of β-naphthols with aryl halides is described. It was found that Q-Phos could facilitate the palladium-catalyzed cross-coupling-type dearomatization of β-naphthols, while avoiding O-arylation, to construct 2-naphthalenones in excellent yields and with high chemoselectivity.

Keywords: cross-coupling; dearomatization; homogeneous catalysis; naphthol; palladium.

Publication types

Research Support, Non-U.S. Gov't