Draft Genome Sequences of Two Drug-Resistant Mycobacterium tuberculosis Isolates from Myanmar

Htin Lin Aung; Thanda Tun; Elizabeth Permina; Wint Wint Nyunt; Si Thu Aung; Kyi Kyi Thinn; John A Crump; Gregory M Cook

doi:10.1128/genomeA.00850-16

Draft Genome Sequences of Two Drug-Resistant Mycobacterium tuberculosis Isolates from Myanmar

Genome Announc. 2016 Oct 27;4(5):e00850-16. doi: 10.1128/genomeA.00850-16.

Authors

Htin Lin Aung¹, Thanda Tun², Elizabeth Permina³, Wint Wint Nyunt⁴, Si Thu Aung⁴, Kyi Kyi Thinn⁵, John A Crump⁶, Gregory M Cook⁷

Affiliations

¹ Department of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand htin.aung@otago.ac.nz.
² National Health Laboratory, Ministry of Health and Sports, Yangon, Myanmar.
³ Otago Genomics and Bioinformatics Facility, University of Otago, Dunedin, New Zealand.
⁴ National TB Programme (NTP), Ministry of Health and Sports, Naypyidaw, Myanmar.
⁵ Department of Microbiology, University of Medicine 1, Yangon, Myanmar.
⁶ Centre for International Health, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
⁷ Department of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.

Abstract

Multidrug-resistant tuberculosis (MDR-TB) and lately, extensively drug-resistant TB (XDR-TB) are increasing global health concerns. Here, we present the genome sequences of two MDR-TB isolates from Myanmar, one of 27 countries with a high MDR-TB burden, and describe a number of mutations consistent with these being XDR-TB isolates.