Oropouche virus is detected in peripheral blood leukocytes from patients

Luciano Kleber de Souza Luna; Alcir Humberto Rodrigues; Rodrigo Ivo Marques Santos; Renata Sesti-Costa; Miriã Ferreira Criado; Ronaldo B Martins; Maria Lúcia Silva; Luana Sella Delcaro; Jose Luiz Proença-Modena; Luiz Tadeu Moraes Figueiredo; Gustavo Olszanski Acrani; Eurico Arruda

doi:10.1002/jmv.24722

Oropouche virus is detected in peripheral blood leukocytes from patients

J Med Virol. 2017 Jun;89(6):1108-1111. doi: 10.1002/jmv.24722. Epub 2017 Feb 24.

Affiliations

¹ Department of Cell and Molecular Biology, Virology Research Center, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil.
² Department of Biochemistry and Immunology, University of Sao Paulo School of Medicine, Ribeirao Preto, São Paulo, Brazil.
³ Department of Internal Medicine, Virology Research Center, University of Sao Paulo School of Medicine, Ribeirao Preto, São Paulo, Brazil.

PMID: 27787907
DOI: 10.1002/jmv.24722

Abstract

Oropouche virus (OROV) is a frequent cause of arboviral febrile disease in the Amazon. The present report describes studies done in two patients, one of them; the first OROV human case acquired outside of the Amazon, which have revealed for the first time the presence of OROV in peripheral blood leukocytes. This novel finding raises important issues regarding pathogenesis of human infections and may offer a new tool, for the rapid diagnosis of this neglected infection. J. Med. Virol. 89:1108-1111, 2017. © 2017 Wiley Periodicals, Inc.

Keywords: Oropouche virus; peripheral blood leukocytes; viremia.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Animals
Bunyaviridae Infections / virology*
Female
Humans
Leukocytes / virology*
Male
Middle Aged
Orthobunyavirus / isolation & purification*