New Insights into the Photophysics of DNA Nucleobases

J Phys Chem Lett. 2016 Nov 17;7(22):4445-4450. doi: 10.1021/acs.jpclett.6b02085. Epub 2016 Oct 27.

Abstract

We report the results of an extended time-resolved study of DNA nucleobases in aqueous solutions conducted in the deep UV using broad-band femtosecond transient absorption and electronic two-dimensional spectroscopies. We found that the photodeactivation in all DNA nucleobases occurs in two steps: fast relaxation (500-700 fs) from the excited state ππ* to a "dark" state and its depopulation to the ground state within 1-2 ps. Our experimental observations and performed theoretical modeling allow us to conclude that this dark state can be associated with the nπ* electronic state, which is connected to the excited and ground states via conical intersections.

MeSH terms

  • DNA*
  • Models, Molecular*
  • Photochemistry
  • Spectrum Analysis*
  • Water

Substances

  • Water
  • DNA