Association Between the Interleukin-10-1082G/A, -592C/A, -819C/T Gene Polymorphism and HIV-1 Susceptibility: A Meta-Analysis

Caixiao Jiang; Shujun Liu; Shuxia Liu; Zhanzhan Li; Peng Chen; Lizhang Chen

doi:10.1089/AID.2016.0056

Association Between the Interleukin-10-1082G/A, -592C/A, -819C/T Gene Polymorphism and HIV-1 Susceptibility: A Meta-Analysis

AIDS Res Hum Retroviruses. 2017 Jan;33(1):61-67. doi: 10.1089/AID.2016.0056. Epub 2016 Nov 28.

Authors

Caixiao Jiang^{1

2}, Shujun Liu³, Shuxia Liu⁴, Zhanzhan Li², Peng Chen⁵, Lizhang Chen²

Affiliations

¹ 1 Hebei Center for Disease Control and Prevention , Shijiazhuang, China .
² 2 Department of Epidemiology and Health Statistics, School of Public Health, Central South University , Changsha, China .
³ 3 Shijiazhuang Center for Disease Control and Prevention , Shijiazhuang, China .
⁴ 4 Liaocheng Center for Disease Control and Prevention , Liaocheng, China .
⁵ 5 Xiangya Medical School, Central South University , Changsha, China .

PMID: 27785918
DOI: 10.1089/AID.2016.0056

Abstract

The Interleukin-10 (IL-10) gene polymorphism influences the pathogenesis and evolution of HIV-1 disease. Many studies in this regard have evaluated the association between this polymorphism and HIV-1 susceptibility, yet, the exact relationship between them remains ambiguous and contradictory. A systematic literature search was conducted and the found case-control studies assessing the association between IL-10-1082G/A, -592C/A, -819C/T gene polymorphism and HIV-1 susceptibility were analyzed. The pooled odds ratios (ORs) and 95% confidence interval (CI) were calculated by a fixed effect model. In general, no significant relationship was found between IL-10-1082G/A gene polymorphism and susceptibility to HIV-1 infection (A vs. G genotype model: OR = 0.97, 95% CI = 0.81-1.23, p = .775; GG vs. AA+AG model: OR = 0.98, 95% CI = 0.76-1.27, p = .867; GG+AG vs. AA model: OR = 0.97, 95% CI = 0.70-1.35, p = .852; GG vs. AA model: OR = 0.88, 95% CI = 0.67-1.15, p = .348; AG vs. AA model: OR = 0.96, 95% CI = 0.67-1.37, p = .811; GG+AA vs. AG model: OR = 1.03, 95% CI = 0.74-1.43, p = .886). IL-10-529C/A gene polymorphism might lead to a decreased risk of HIV-1 infection (A vs. G genotype model: OR = 0.88, 95% CI = 0.73-1.06, p = .166; GG vs. AA+AG model: OR = 0.94, 95% CI = 0.80-1.11, p = .447; GG+AG vs. AA model: OR = 0.75, 95% CI = 0.61-0.92, p = .005; GG vs. AA model: OR = 0.73, 95% CI = 0.57-0.93, p = .012; AG vs. AA model: OR = 0.74, 95% CI = 0.60-0.92, p = .0.007; GG+AA vs. AG model: OR = 1.11, 95% CI = 0.72-1.71, p = .641). IL-10-819C/T gene polymorphism might lead to an increased risk of HIV-1 infection (A vs. G genotype model: OR = 1.25, 95% CI = 1.04-1.50, p = .019; GG vs. AA+AG model: OR = 1.29, 95% CI = 0.81-2.01, p = .278; GG+AG vs. AA model: OR = 1.42, 95% CI = 1.05-1.93, p = .023; GG vs. AA model: OR = 1.63, 95% CI = 1.11-2.38, p = .012; AG vs. AA model: OR = 1.32, 95% CI = 0.95-1.84, p = .094; GG+AA vs. AG model: OR = 0.92, 95% CI = 0.72-1.19, p = .537). In general, the meta-analysis found no marked association between the IL-10-1082G/A gene polymorphism and HIV-1 susceptibility, IL-10-529C/A gene polymorphism might lead to a decreased risk of HIV-1 infection, and IL-10-819C/T gene polymorphism might lead to an increased risk of HIV-1 infection.

Keywords: HIV-1; IL-10; meta-analysis; polymorphism; susceptibility.

Publication types

Meta-Analysis
Review

MeSH terms

Gene Frequency
Genetic Predisposition to Disease*
HIV Infections / genetics*
Humans
Interleukin-10 / genetics*
Polymorphism, Single Nucleotide*

Substances

IL10 protein, human
Interleukin-10