Invariant death

F1000Res. 2016 Aug 25:5:2076. doi: 10.12688/f1000research.9456.1. eCollection 2016.

Abstract

In nematodes, environmental or physiological perturbations alter death's scaling of time. In human cancer, genetic perturbations alter death's curvature of time. Those changes in scale and curvature follow the constraining contours of death's invariant geometry. I show that the constraints arise from a fundamental extension to the theories of randomness, invariance and scale. A generalized Gompertz law follows. The constraints imposed by the invariant Gompertz geometry explain the tendency of perturbations to stretch or bend death's scaling of time. Variability in death rate arises from a combination of constraining universal laws and particular biological processes.

Keywords: Gompertz distribution; Mortality; cancer; nematodes; probability theory.

Grants and funding

National Science Foundation grant DEB–1251035 supports my research.