Persistent Corneal Edema Associated With Subconjunctival 5-fluorouracil in an Infant With Primary Congenital Glaucoma

J Pediatr Ophthalmol Strabismus. 2016 Oct 22:53:e54-e57. doi: 10.3928/01913913-20161003-01.

Abstract

A 3-month-old boy with primary congenital glaucoma developed a transient corneal endothelial opacity after needle bleb revision with adjunctive 5-fluorouracil. This case presents a rare toxicity that, although transient, is concerning due to the potential of amblyopia. The authors review prior cases of corneal opacity associated with 5-fluorouracil. [J Pediatr Ophthalmol Strabismus. 2016;53:e54-e57.].

Publication types

  • Case Reports

MeSH terms

  • Antimetabolites / adverse effects*
  • Conjunctiva
  • Corneal Edema / chemically induced*
  • Fluorouracil / adverse effects*
  • Humans
  • Hydrophthalmos / drug therapy
  • Hydrophthalmos / surgery
  • Hydrophthalmos / therapy*
  • Infant
  • Injections, Intraocular
  • Male
  • Needles

Substances

  • Antimetabolites
  • Fluorouracil