WASP and WAVE Team Up at the Leading Edge

Nicolas Molinie; Alexis Gautreau

doi:10.1016/j.devcel.2016.10.008

WASP and WAVE Team Up at the Leading Edge

Dev Cell. 2016 Oct 24;39(2):135-136. doi: 10.1016/j.devcel.2016.10.008.

Authors

Nicolas Molinie¹, Alexis Gautreau²

Affiliations

¹ Ecole Polytechnique, Université Paris-Saclay, CNRS UMR7654, 91120 Palaiseau, France.
² Ecole Polytechnique, Université Paris-Saclay, CNRS UMR7654, 91120 Palaiseau, France. Electronic address: alexis.gautreau@polytechnique.edu.

PMID: 27780037
DOI: 10.1016/j.devcel.2016.10.008

Abstract

Arp2/3-dependent branched actin networks drive membrane protrusions, with WAVE being recognized as the critical Arp2/3 activator in this process. In this issue of Developmental Cell, Zhu et al. (2016) demonstrate that WASP, an Arp2/3 activator mostly involved in endocytosis, collaborates with WAVE to promote migration of neuroblasts in Caenorhabditis elegans.

Publication types

Comment

MeSH terms

Actin-Related Protein 2-3 Complex*
Actins
Animals
Caenorhabditis elegans
Endocytosis
Wiskott-Aldrich Syndrome Protein*

Substances

Actin-Related Protein 2-3 Complex
Actins
Wiskott-Aldrich Syndrome Protein