Heat FLiPs a Hormonal Switch for Longevity

Murat Artan; Seon Woo A An; Seung-Jae V Lee

doi:10.1016/j.devcel.2016.10.004

Heat FLiPs a Hormonal Switch for Longevity

Dev Cell. 2016 Oct 24;39(2):133-134. doi: 10.1016/j.devcel.2016.10.004.

Authors

Murat Artan¹, Seon Woo A An¹, Seung-Jae V Lee²

Affiliations

¹ Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
² Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea; School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea. Electronic address: seungjaelee@postech.ac.kr.

PMID: 27780036
DOI: 10.1016/j.devcel.2016.10.004

Abstract

Temperature-sensing neurons in C. elegans reduce the life-shortening effects of high temperatures via steroid signaling. In this issue of Developmental Cell, Chen et al. (2016) elucidate the underlying mechanisms by which the transcription factor CREB induces the neuropeptide FLP-6 in the temperature-sensing neurons to counteract the life-shortening effects of high temperature.

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MeSH terms

Animals
Caenorhabditis elegans Proteins
Caenorhabditis elegans*
Hot Temperature
Longevity*
Transcription Factors

Substances

Caenorhabditis elegans Proteins
Transcription Factors