PLC-β1 and cell differentiation: An insight into myogenesis and osteogenesis

Giulia Ramazzotti; Irene Faenza; Roberta Fiume; Anna Maria Billi; Lucia Manzoli; Sara Mongiorgi; Stefano Ratti; James A McCubrey; Pann-Ghill Suh; Lucio Cocco; Matilde Y Follo

doi:10.1016/j.jbior.2016.10.005

PLC-β1 and cell differentiation: An insight into myogenesis and osteogenesis

Adv Biol Regul. 2017 Jan:63:1-5. doi: 10.1016/j.jbior.2016.10.005. Epub 2016 Oct 18.

Affiliations

¹ Cellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy. Electronic address: giulia.ramazzotti@unibo.it.
² Cellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
³ Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, USA.
⁴ Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.

PMID: 27776973
DOI: 10.1016/j.jbior.2016.10.005

Abstract

Phosphoinositide-phospholipase C-β1 (PLC-β1) plays a crucial role in the initiation of the genetic program responsible for muscle differentiation and osteogenesis. During myogenic differentiation of murine C2C12 myoblasts, PLC-β1 signaling pathway involves the Inositol Polyphosphate Multikinase (IPMK) and β-catenin as downstream effectors. By means of c-jun binding to cyclin D3 promoter, the activation of PLC-β1 pathway determines cyclin D3 accumulation. However, osteogenesis requires PLC-β1 expression and up-regulation but it does not affect cyclin D3 levels, suggesting that the two processes require the activation of different mediators.

Publication types

Review

MeSH terms

Animals
Cell Differentiation
Cell Line
Cyclin D3 / genetics
Cyclin D3 / metabolism
Gene Expression Regulation, Developmental
JNK Mitogen-Activated Protein Kinases / genetics
JNK Mitogen-Activated Protein Kinases / metabolism
Mice
Muscle Development / genetics*
Myoblasts / cytology
Myoblasts / metabolism*
Osteoblasts / cytology
Osteoblasts / metabolism*
Osteogenesis / genetics*
Phospholipase C beta / genetics*
Phospholipase C beta / metabolism
Phosphotransferases (Alcohol Group Acceptor) / genetics
Phosphotransferases (Alcohol Group Acceptor) / metabolism
Promoter Regions, Genetic
Protein Binding
Signal Transduction
beta Catenin / genetics
beta Catenin / metabolism

Substances

CTNNB1 protein, mouse
Ccnd3 protein, mouse
Cyclin D3
beta Catenin
Phosphotransferases (Alcohol Group Acceptor)
inositol polyphosphate multikinase
JNK Mitogen-Activated Protein Kinases
Phospholipase C beta
Plcb1 protein, mouse