Germinated Pigmented Rice (Oryza Sativa L. cv. Superhongmi) Improves Glucose and Bone Metabolisms in Ovariectomized Rats

Nutrients. 2016 Oct 21;8(10):658. doi: 10.3390/nu8100658.

Abstract

The effect of germinated Superhongmi, a reddish brown pigmented rice cultivar, on the glucose profile and bone turnover in the postmenopausal-like model of ovariectomized rats was determined. The ovariectomized Sprague-Dawley rats were randomly divided into three dietary groups (n = 10): normal control diet (NC) and normal diet supplemented with non-germinated Superhongmi (SH) or germinated Superhongmi (GSH) rice powder. After eight weeks, the SH and GSH groups showed significantly lower body weight, glucose and insulin concentrations, levels of bone resorption markers and higher glycogen and 17-β-estradiol contents than the NC group. The glucose metabolism improved through modulation of adipokine production and glucose-regulating enzyme activities. The GSH rats exhibited a greater hypoglycemic effect and lower bone resorption than SH rats. These results demonstrate that germinated Superhongmi rice may potentially be useful in the prevention and management of postmenopausal hyperglycemia and bone turnover imbalance.

Keywords: Superhongmi; bone metabolism; germination; glucose; pigmented rice.

MeSH terms

  • Adipokines / biosynthesis
  • Animals
  • Biomarkers / blood
  • Blood Glucose / metabolism*
  • Body Weight / drug effects
  • Bone Resorption / blood*
  • Bone Resorption / diet therapy
  • Bone and Bones / drug effects*
  • Bone and Bones / metabolism
  • Dietary Supplements
  • Estradiol / blood
  • Female
  • Germination
  • Glycogen / blood
  • Hyperglycemia / blood*
  • Hyperglycemia / diet therapy
  • Hyperglycemia / enzymology
  • Hypoglycemic Agents / pharmacology*
  • Insulin / blood
  • Oryza*
  • Ovariectomy
  • Postmenopause
  • Random Allocation
  • Rats, Sprague-Dawley

Substances

  • Adipokines
  • Biomarkers
  • Blood Glucose
  • Hypoglycemic Agents
  • Insulin
  • Estradiol
  • Glycogen