Radiosynthesis of SPECT tracers via a copper mediated 123I iodination of (hetero)aryl boron reagents

Chem Commun (Camb). 2016 Nov 3;52(90):13277-13280. doi: 10.1039/c6cc07417k.

Abstract

A general method for the copper mediated nucleophilic 123I-iodination of (hetero)aryl boronic esters and acids has been developed. The broad substrate scope of this radiosynthetic approach allows access to [123I]DPA-713, [123I]IMPY, [123I]MIBG and [123I]IPEB that are four commonly used SPECT radiotracers. Our results infer that aryl boronic reagents can now be employed as common precursors for both fluorine-18 and iodine-123 radiolabelling.