1 Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College, London, United Kingdom.
2 Bristol Heart Institute and Clinical Trials & Evaluation Unit, University of Bristol, Bristol, United Kingdom.
3 Bristol Heart Institute and Clinical Trials & Evaluation Unit, University of Bristol, Bristol, United Kingdom; Department of Cardiothoracic Surgery, Imperial College, London, United Kingdom.
4 Department of Cardiovascular Science, University of Sheffield, Sheffield, S10 2RX, United Kingdom. Electronic address: paul.evans@sheffield.ac.uk.