Nanoparticles for cancer gene therapy: Recent advances, challenges, and strategies

Pharmacol Res. 2016 Dec:114:56-66. doi: 10.1016/j.phrs.2016.10.016. Epub 2016 Oct 19.

Abstract

Compared to conventional treatments, gene therapy offers a variety of advantages for cancer treatment including high potency and specificity, low off-target toxicity, and delivery of multiple genes that concurrently target cancer tumorigenesis, recurrence, and drug resistance. In the past decades, gene therapy has undergone remarkable progress, and is now poised to become a first line therapy for cancer. Among various gene delivery systems, nanoparticles have attracted much attention because of their desirable characteristics including low toxicity profiles, well-controlled and high gene delivery efficiency, and multi-functionalities. This review provides an overview on gene therapeutics and gene delivery technologies, and highlight recent advances, challenges and insights into the design and the utility of nanoparticles in gene therapy for cancer treatment.

Keywords: Cancer gene therapy; Gene delivery; Nanoparticles.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Gene Expression Regulation, Neoplastic
  • Gene Transfer Techniques*
  • Genetic Therapy / methods*
  • Humans
  • Immunotherapy / methods
  • Nanomedicine / methods
  • Nanoparticles / administration & dosage
  • Nanoparticles / chemistry*
  • Nanotechnology / methods
  • Neoplasms / genetics*
  • Neoplasms / therapy*