Synthesis, nematocidal activity and SAR study of novel difluoromethylpyrazole carboxamide derivatives containing flexible alkyl chain moieties

Eur J Med Chem. 2017 Jan 5:125:881-889. doi: 10.1016/j.ejmech.2016.10.017. Epub 2016 Oct 10.

Abstract

A series of novel difluoromethylpyrazole carboxamides derivatives were synthesized by introduction of flexible alkyl chain. Nematicidal bioassay results showed that some of them exhibited good control efficacy against M. incognita, which indicated that these difluoromethylpyrazole carboxamides derivatives might be potential novel lead compounds for discovery new nematicides. The nematicidal activity was affected by the substituted position in the molecule, especially the substitution group on the alkyl chain. It was found that the compound 6-9 and 6-23 possess about 50% inhibition effect against M. incognita even at 5.0 and 1.0 mg L-1. Meanwhile, greenhouse field trial showed the nematicidal activity of compound 6-9 is a litter weaker than that of Abamectin. The mammalian toxicology results indicated that compound 6-9 was a low-toxicity and low-sensitive compound. In conclusion compound 6-9 is a potential candidate for further development. In addition, the molecular docking simulations revealed that compounds 6 with a flexible NHCOO show its binding affinities for the acetylcholine receptor (AChR), which may provide useful information for further design novel nematicides.

Keywords: Difluoromethylpyrazole carboxamide; Docking; Flexible chain; Nematicidal activity.

MeSH terms

  • Amides
  • Animals
  • Antinematodal Agents / chemistry*
  • Antinematodal Agents / pharmacology
  • Drug Design
  • Mammals
  • Molecular Docking Simulation
  • Nematoda / drug effects
  • Protein Binding / drug effects
  • Pyrazoles / chemical synthesis
  • Pyrazoles / pharmacology
  • Pyrazoles / therapeutic use*
  • Receptors, Cholinergic / metabolism
  • Structure-Activity Relationship
  • Tylenchoidea / drug effects*

Substances

  • Amides
  • Antinematodal Agents
  • Pyrazoles
  • Receptors, Cholinergic