Neutralizing Antibodies to Severe Fever with Thrombocytopenia Syndrome Virus 4 Years after Hospitalization, China

Emerg Infect Dis. 2016 Nov;22(11):1985-1987. doi: 10.3201/eid2211.160414.

Abstract

Severe fever with thrombocytopenia syndrome is an emerging hemorrhagic fever disease in eastern Asia, caused by a tickborne bunyavirus. Of 25 patients hospitalized with this disease in China, 100% produced and maintained neutralizing antibodies to severe fever with thrombocytopenia syndrome virus for the study period of 4 years.

Keywords: China; SFTS; SFTSV; bunyavirus; hemorrhagic fever; neutralizing antibodies; plaque assay; severe fever with thrombocytopenia syndrome; severe fever with thrombocytopenia syndrome virus; viruses.

MeSH terms

  • Adult
  • Aged
  • Antibodies, Neutralizing / blood
  • Antibodies, Neutralizing / immunology*
  • Antibodies, Viral / blood
  • Antibodies, Viral / immunology*
  • China / epidemiology
  • Communicable Diseases, Emerging / epidemiology
  • Communicable Diseases, Emerging / immunology
  • Communicable Diseases, Emerging / virology
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Hospitalization*
  • Humans
  • Male
  • Middle Aged
  • Neutralization Tests
  • Phlebotomus Fever / epidemiology*
  • Phlebotomus Fever / immunology*
  • Phlebotomus Fever / virology
  • Phlebovirus / classification
  • Phlebovirus / genetics
  • Phlebovirus / immunology*
  • RNA, Viral

Substances

  • Antibodies, Neutralizing
  • Antibodies, Viral
  • RNA, Viral