In recent years, there has been an exponential rise in the number of reports describing synthetic methods that utilize catalytic sp3 and sp2 C-H bond activation. Many have emerged as powerful synthetic tools for accessing biologically active motifs. Indeed, application to C-C and C-heteroatom bond formation, provides new directives for the construction of new pharmaceutical entities. Herein, we highlight some recent novel C-H activation processes that exemplify the utility of these transformations in medicinal chemistry.
Keywords: C–H activation; Drug discovery; Heterocycles; Medicinal chemistry; Pharmaceuticals.
Copyright © 2016 Elsevier Ltd. All rights reserved.