Synaptic Suppression of Axon Regeneration

Jessica M Meves; Binhai Zheng

doi:10.1016/j.neuron.2016.10.012

Synaptic Suppression of Axon Regeneration

Neuron. 2016 Oct 19;92(2):267-269. doi: 10.1016/j.neuron.2016.10.012.

Authors

Jessica M Meves¹, Binhai Zheng²

Affiliations

¹ Neurosciences Graduate Program and Department of Neurosciences, University of California San Diego, School of Medicine, 9500 Gilman Drive, MC 0691, La Jolla, CA 92093, USA.
² Neurosciences Graduate Program and Department of Neurosciences, University of California San Diego, School of Medicine, 9500 Gilman Drive, MC 0691, La Jolla, CA 92093, USA. Electronic address: binhai@ucsd.edu.

PMID: 27764657
DOI: 10.1016/j.neuron.2016.10.012

Abstract

In this issue of Neuron, Tedeschi et al. (2016) describe the voltage-gated calcium channel subunit alpha2delta2 as a developmental switch from axon elongation to synapse formation and transmission that doubles as a suppressor of axon regeneration, providing a molecular clue for the synaptic stabilization hypothesis of CNS regeneration failure.

MeSH terms

Axons*
Humans
Neurogenesis
Neurons*
Regeneration

Abstract

MeSH terms

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